CARNIFLEX® is a tablet for maintaining healthy joints and to support flexible movement in dogs and cats. Carniflex® is also used to meet the increased need for nutrients of the musculoskeletal system at high load and in the growth phase.
Joint diseases in pets cause a great deal of pain and result in functional movement disorders. Joints can be damaged by an acute trauma, chronic overload or old age.
Joint cartilage is mainly made up of three elements that offer flexibility, elasticity and firmness: proteoglycans to attract and retain water, collagen to fixate the proteoglycans and cartilage cells. The cartilage cells play an important role in maintaining the integrity of the tissue by means of the synthesis of collagen, proteoglycans and enzymes of the cartilage metabolism.
In case of non-infectious osteoarthritis an inflammatory process is triggered, whereby the collagen and the proteoglycans are damaged by proteolytic enzymes, the matrix metalloproteinases (MMPs). The cartilage cells produce proinflammatory cytokines which activate the MMPs. In healthy cartilage there is a balance between the MMPs and their inhibitors, which produces a perfect control and homeostasis of the cartilage. In case of an imbalance the inflamed cartilage cells are no longer capable of synthesising new cartilage.
The occurrence of arthritis increases with age and affects the large, weight-bearing joints.
CARNIFLEX® reduces the effect of proinflammatory cytokines and therefore reduces the MMP concentration.
CARNIFLEX® contains free amino acids for the synthesis of collagen and glucosamine sulfate for the synthesis of proteoglycans, as well as cofactors required for the adequate functioning of enzymes involved in the process.
CARNIFLEX® increases the synthesis of the glycosaminoglycans chondroitine sulfate and hyaluronic acid in the joint fluid and the cartilage matrix. The viscosity of the joint fluid is primarily dependent on the concentration of hyaluronic acid. Glycosaminoglycans (GAGs) are bound to a core protein to form proteoglycans. Proteoglycans can be found in the extracellular cartilage matrix (ECM).
CARNIFLEX® contains the natural antioxidant pomegranate extract which protects the cartilage cells by reducing the production of superoxide radicals that damage the tissue.
CARNIFLEX® contains roasted meat aroma to guarantee the delicious taste.
CARNIFLEX® contains undenatured type II collagen in low doses, allowing to interact with the immune system. When cartilage is damaged, fragments (foreign to the body) are released into the synovial fluid. The immune system responds (immune response) with an inflammatory reaction in which antibodies against type II collagen are formed. Supplementation of undenatured type II collagen in low doses (milligrammes) desensitises the immune system so that further degeneration of the collagen fibres is prevented. When taken orally, specific parts (epitopes) of the intact helix structure are recognised by the immune system near the Peyer's patch in the last part of the small intestinal wall (ileum). After contact between undenatured type II collagen and the Peyer's patch, regulatory T-cells (Tregs) in the intestinal mucosa suppress the defence mechanism. The specifically formed regulatory T-cells migrate to the joint and reduce the inflammatory response. This working mechanism is called oral tolerance.
1 tablet CARNIFLEX® contains: 750 mg glucosamine sulfate, 335 mg cellulose, 110 mg dextrin, 1.60 mg undenatured type II collagen, 35 mg L-alanine, 100 mg L-glycine, 10 mg L-hydroxyproline, 25 mg L-lysine, 50 mg L-proline, 50 mg S-adenosylmethionine, 3 mg vitamin B6 (pyridoxine HCL), 90 mg vitamin C (L-ascorbic acid), 1.50 mg manganese sulfate, 30 mg silicon dioxide, 50 mg magnesium stearate, 250 mg pomegranate extract, 100 mg lecithin (phosphatidylcholine) and 40 mg roasted meat aroma.
Body weight < 20 kg: ½ tablet daily at bedtime for 2 to 3 months
Body weight > 20 kg: 1 tablet daily at bedtime for 2 to 3 months
If necessary, crush the tablet.
CARNIFLEX® is packaged in a box of 30 tablets in blisters.
CARNIFLEX® is safe for unlimited treatment duration. Carniflex® can also be safely administered during gestation.
CARNIFLEX® is freely available.